Primary sclerosing cholangitis: diagnostic and management challenges

Primary sclerosing cholangitis: diagnostic and management challenges

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Sanjeev Sirpal,1 Natasha Chandok2 1Department of Medicine, Centre Hospitalier de l’Université de Montréal (CHUM), University of Montreal, Montreal, QC, 2Department of Medicine, University of Western Ontario, London, ON, copyright Abstract: Primary sclerosing cholangitis (PSC) is a chronic immune-mediated disease affecting here intra- and extrahepatic bile ducts, primarily the large biliary ducts.Clinical manifestations are broad, and the spectrum encompasses asymptomatic cholestasis, icteric cholangitis with pruritis, cirrhosis, and cholangiocarcinoma.Though rare, PSC has a propensity to affect young to middle-aged males and is strongly associated with inflammatory bowel disease.There is an unmet need iphone 13 pro max price florida for effective medical treatments for PSC, and to date, the only curative therapy is liver transplantation reserved for those with end-stage liver disease.

This article addresses the diagnostic and management challenges of PSC, with a succinct analysis of existing therapies, their limitations, and a glimpse into the future of the management of this multifaceted pathologic entity.Keywords: primary sclerosing cholangitis, management, PSC.